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The story of Alec Clowes, Eli Lilly & Company, and the discovery of insulin is part of Indianapolis legend and has been told by others. We know far less, however, about Alec Clowes’s idiosyncratic personality, and even less about his wife Edith Whitehill Clowes, despite the couple’s prominence in the Indianapolis community. The Doc and the Duchess offers a fine study of Alec Clowes the family man, scientist, executive, and philanthropist. Anyone interested in the Clowes family, Eli Lilly & Company, philanthropy, or Indianapolis history will enjoy reading this unique work.