Serotonin System Dysfunction and Callous-Unemotional Behavior
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Abstract
Callous-unemotional behavior is a pattern of behavior in children involving lack of empathy and remorse, impulsivity, antisocial behavior, and potentially criminal or violent behavior. Due to a lack of effective treatment, callous-unemotional behavior tends to be treated as a personal choice rather than a mental disorder. This paper attempts to provide an explanation for some of the biological causes for callous-unemotional behavior. A better understanding of the biological causes can influence the direction of research into treatments, as well as the general perception of the condition. The serotonin system seems to play a large role in the development of callous-unemotional traits. This paper will discuss the genetic, environmental, and epigenetic factors that lead to serotonin system dysfunction, and the effects of this dysfunction on children. Additionally, this paper discusses the potential for selective serotonin reuptake inhibitors (SSRIs) to be used in treatment of callous-unemotional behavior.
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