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Problem-based learning can be an effective educational approach for students entering the health care field. While broadly used in graduate and professional education in the health sciences, it is less widely used in undergraduate programs. We discuss the use of problem-based learning as part of an approach to address failure rates in select Health Sciences courses, poor critical thinking skills and bottlenecks in enrollment. While our results were mixed, we saw an overall improvement in student outcomes. Problem-based learning experiences prepare students successfully for demands of the real world.