SPECIFICITY OF TMS EFFECTS ON M1 AND S1

Loading...
Thumbnail Image
Can’t use the file because of accessibility barriers? Contact us with the title of the item, permanent link, and specifics of your accommodation need.

Date

2022-05

Journal Title

Journal ISSN

Volume Title

Publisher

[Bloomington, Ind.] : Indiana University

Abstract

The region of the human brain known as the sensorimotor cortex is composed of the primary motor cortex (M1) and the primary somatosensory cortex (S1). M1 codes for voluntary movement and S1 processes touch, position sense, and related sensory information. While the neighboring cortices of M1 and S1 are interconnected and reciprocally interact, they are also thought to be separately modulated by stimulation. This study asks if stimulating M1 or S1 has distinguishable effects on motor and tactile processing. Participants received non-invasive transcranial magnetic stimulation (TMS) in a repetitive pattern thought to inhibit cortical activity (continuous theta burst stimulation, or cTBS). This intervention was delivered over M1 or S1. A third group received sham stimulation. Pre- and post-cTBS, motor excitability was assessed with single TMS pulses over M1 and tactile processing was assessed with the 2-point discrimination test (2PD) or the grating orientation test (GOT). Results did not detect a distinguishable effect of cTBS on either motor or tactile processing. This could indicate that the cTBS protocol is not focal enough to cause distinguishable effects in M1 vs. S1, or it could indicate that a larger study would be needed to have sufficient power to detect such effects.

Description

Thesis (M.S.) - Indiana University, School of Public Health, 2022

Keywords

Transcranial magnetic stimulation, motor and sensory processing, theta burst stimulation

Citation

Journal

DOI

Link(s) to data and video for this item

Relation

Rights

Type

Thesis

Collections