SPECIFICITY OF TMS EFFECTS ON M1 AND S1
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Date
2022-05
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[Bloomington, Ind.] : Indiana University
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Abstract
The region of the human brain known as the sensorimotor cortex is composed of the primary motor cortex (M1) and the primary somatosensory cortex (S1). M1 codes for voluntary movement and S1 processes touch, position sense, and related sensory information. While the neighboring cortices of M1 and S1 are interconnected and reciprocally interact, they are also thought to be separately modulated by stimulation. This study asks if stimulating M1 or S1 has distinguishable effects on motor and tactile processing. Participants received non-invasive transcranial magnetic stimulation (TMS) in a repetitive pattern thought to inhibit cortical activity (continuous theta burst stimulation, or cTBS). This intervention was delivered over M1 or S1. A third group received sham stimulation. Pre- and post-cTBS, motor excitability was assessed with single TMS pulses over M1 and tactile processing was assessed with the 2-point discrimination test (2PD) or the grating orientation test (GOT). Results did not detect a distinguishable effect of cTBS on either motor or tactile processing. This could indicate that the cTBS protocol is not focal enough to cause distinguishable effects in M1 vs. S1, or it could indicate that a larger study would be needed to have sufficient power to detect such effects.
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Thesis (M.S.) - Indiana University, School of Public Health, 2022
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Transcranial magnetic stimulation, motor and sensory processing, theta burst stimulation
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Thesis