Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes

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A three-component coupling of aryl bromides, arylboron reagents, and alkenylarenes is presented. The method tolerates a variety of substitution patterns on all of the components. In particular, 1,2-disubstituted alkenylarenes are suitable and undergo highly diastereoselective diarylation.

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Gao, P., et al. "Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes." Journal of the American Chemical Society, vol. 140, no. 34, pp. 10653-10657, 2018-08-20, https://doi.org/10.1021/jacs.8b05680.

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Journal of the American Chemical Society

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