Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine

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dc.contributor.authorBrown, M. Kevin
dc.contributor.authorGuo, Renyu
dc.contributor.authorWitherspoon, Brittany
dc.date.accessioned2022-02-07T15:52:18Z
dc.date.available2022-02-07T15:52:18Z
dc.date.issued2020
dc.description.abstractThe first enantioselective synthesis of (−)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.
dc.identifier.citationGuo, R.; Witherspoon, B. P.; Brown, M. K. Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine. J. Am. Chem. Soc. 2020, 142 (11), 5002–5006.
dc.identifier.doihttps://doi.org/10.1021/jacs.0c00359
dc.identifier.urihttps://hdl.handle.net/2022/27123
dc.language.isoen
dc.publisherJournal of the American Chemical Society
dc.relation.isversionofhttps://pubs.acs.org/doi/10.1021/jacs.0c00359
dc.relation.isversionofhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252469/
dc.rightsThis work may be protected by copyright unless otherwise stated.
dc.titleEvolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine
dc.typeArticle

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