Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine

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https://pubs.acs.org/doi/10.1021/jacs.0c00359
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252469/

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2020

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Journal of the American Chemical Society

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https://hdl.handle.net/2022/27123

Abstract

The first enantioselective synthesis of (−)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0]bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed.

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Guo, R.; Witherspoon, B. P.; Brown, M. K. Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine. J. Am. Chem. Soc. 2020, 142 (11), 5002–5006.

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https://doi.org/10.1021/jacs.0c00359

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Jonathan Karty Research Collection