Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

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dc.contributor.authorSchwarz, Kevin J.
dc.contributor.authorPearson, Colin Matthew
dc.contributor.authorCintron-Rosado, Gabriel A.
dc.contributor.authorLiu, Peng
dc.contributor.authorSnaddon, Thomas Neil
dc.date.accessioned2025-02-20T16:16:12Z
dc.date.available2025-02-20T16:16:12Z
dc.date.issued2018-04-27
dc.description.abstractCooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters using 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and the source of enantiocontrol are independent. This feature is unique to simultaneous catalysis events and permits logical tuning of the supporting ligands without compromising enantioselectivity.
dc.identifier.citationSchwarz, Kevin J., et al. "Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles." Angewandte Chemie International Edition, vol. 57, no. 26, pp. 7800-7803, 2018-04-27, https://doi.org/10.1002/anie.201803277.
dc.identifier.otherBRITE 3902
dc.identifier.urihttps://hdl.handle.net/2022/30566
dc.language.isoen
dc.relation.isversionofhttps://doi.org/10.1002/anie.201803277
dc.relation.isversionofhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038818
dc.relation.journalAngewandte Chemie International Edition
dc.rightsThis work may be protected by copyright unless otherwise stated.
dc.titleTraversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

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