Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

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https://doi.org/10.1002/anie.201803277
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038818

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2018-04-27

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https://hdl.handle.net/2022/30566

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Cooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters using 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and the source of enantiocontrol are independent. This feature is unique to simultaneous catalysis events and permits logical tuning of the supporting ligands without compromising enantioselectivity.

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Schwarz, Kevin J., et al. "Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles." Angewandte Chemie International Edition, vol. 57, no. 26, pp. 7800-7803, 2018-04-27, https://doi.org/10.1002/anie.201803277.

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Angewandte Chemie International Edition

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Faculty Open Access Articles