The role of lipocalin-2 in age-related macular degeneration (AMD)

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dc.contributor.authorGhosh, Sayan
dc.contributor.authorStepicheva, Nadezda
dc.contributor.authorYazdankhah, Meysam
dc.contributor.authorShang, Peng
dc.contributor.authorWatson, Alan M.
dc.contributor.authorHose, Stacey
dc.contributor.authorLiu, Haitao
dc.contributor.authorWeiss, Joseph
dc.contributor.authorZigler, J. Samuel Jr.
dc.contributor.authorValapala, Mallika
dc.contributor.authorWatkins, Simon C.
dc.contributor.authorSinha, Debasish
dc.date.accessioned2025-02-20T15:48:29Z
dc.date.available2025-02-20T15:48:29Z
dc.date.issued2020-01-04
dc.description.abstractLipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.
dc.identifier.citationGhosh, Sayan, et al. "The role of lipocalin-2 in age-related macular degeneration (AMD)." Cellular and Molecular Life Sciences, 2020-01-04, https://doi.org/10.1007/s00018-019-03423-8.
dc.identifier.issn1420-682X
dc.identifier.otherBRITE 7064
dc.identifier.urihttps://hdl.handle.net/2022/32114
dc.language.isoen
dc.relation.isversionofhttps://doi.org/10.1007/s00018-019-03423-8
dc.relation.isversionofhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079812
dc.relation.journalCellular and Molecular Life Sciences
dc.titleThe role of lipocalin-2 in age-related macular degeneration (AMD)

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