Testing effects of the SSRI drug Paroxetine on survival of a freshwater amphipod (Hyalella sp.)

Abstract

Serotonin selective reuptake inhibitors (SSRIs) are drugs that typically are used as antidepressants and as treatment for anxiety in humans. It has been realized that these drugs are showing up in bodies of water from our waste water. As these drugs pollute the waterways, it can negatively growth, survival, or reproduction in aquatic organisms. The main goals of my study were to develop protocols for maintaining healthy amphipod (Hyalella species) cultures in the lab, and test how well amphipods were able to survive when exposed to different concentrations of the SSRI drug paroxetine (Paxil). Amphipods in the Genus Hyalella are common in lakes and rivers throughout the Midwest. Larger volumes of water (30 mL), maximizing air/water surface (to increase oxygen levels) and some vegetation are needed to maintain healthy Hyalella cultures. Even small concentrations of the paroxetine SSRI drug can kill freshwater amphipods.