Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Abstract

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−$^{10} $), 3p22.1 (rs67311347, P=2.5 × 10−$^8$), 3q26.2 (rs10936602, P=8.8 × 10−$^9$), 8p21.3 (rs2241261, P=5.8 × 10−$^9$), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−$^8$), 11q22.3 (rs74911261, P=2.1 × 10−$^{10}$) and 14q24.2 (rs4903064, P=2.2 × 10−$^{24}$). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.