Investigating Inhibitors Against Quorum Sensing Group Behaviors in V. Vulnificus

Abstract

The gradual development of superbugs has led to more and more problems when fighting infections. Finding ways to prevent group behaviors and decrease virulence possibly offers a path for fighting infection without adding to antibiotic resistance. This study found several new inhibitors that prevent activity from the transcription factor SmcR, which is what activates group behaviors caused by quorum sensing in V. vulnificus. These inhibitors 32A, 32C, and 18C are more effective than previously found inhibitors for LuxR homologs. Through these findings, structural patterns between inhibitors emerge. Assay data and docking studies were used for these findings. This information is used to propose new compounds for future testing of their inhibitory effectiveness against SmcR.