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Recent Submissions

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    Evaluation of Small-Molecule Inhibitors Targeting Vibrio Quorum Sensing Transcription Factor LuxR
    (2026-07-13) Lah, Ian; Hosey, Elie; Livingston, Eileen; Battaglia, Blake; Declan, Oliver-Raikes; Aloys, Karim; Graber, Anna; Nair, Anagha; van Kessel, Dr. Julia; Brown, Dr. Laura
    Pathogenic Vibrio species rely on quorum sensing (QS) to coordinate virulence and group behaviors, presenting a severe threat to human health, marine ecosystems, and global aquaculture. Antibiotic resistance necessitates the development of novel, alternative treatments that disarm pathogens without selectively pressuring bacterial survival. To address this, we evaluated a series of small-molecule inhibitors designed to disrupt the function of LuxR and its homologs, which serve as the master transcriptional regulators of QS in Vibrio species. Through a combination of transcriptional reporter assays, in vitro binding evaluations, and structural modeling, we identified several potent compounds that successfully reduced LuxR-driven gene expression. Importantly, our top candidate inhibitors reduced LuxR-driven reporter expression without substantially affecting overall bacterial growth. These findings support the viability of targeting LuxR-like transcription factors as an anti-virulence strategy, providing a strong foundation for the development of more potent inhibitors through lead optimization, and ultimately next-generation therapeutics to combat drug-resistant Vibrio infections.
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    SACO Submissions for Non-SACO Members
    (2026-07-10) Sewald, Ronda
    Presentation on various options for proposing subject headings to the Library of Congress Subject Authority File for catalogers who are not members of the Program for Cooperative Cataloging's (PCC) SACO program including obtaining SACO membership, the Library of Congress's pdf submission form, and SACO funnels. The presentation also provides information on what the ClassWeb Plus submission process looks like and troubleshooting tips for catalogers who belong to SACO but are unable to access the proposal menu.
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    Book Review. History of Legal Education
    (1983-01-01) Shreve, Gene R.
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