Show simple item record Kinney, Michael P. Panting, Nicholas D. Clark, Thomas M. 2021-06-29T16:28:27Z 2021-06-29T16:28:27Z 2014
dc.description.abstract The effects of the serotonin-selective reuptake inhibitor paroxetine (2×10–5 mol l–1) on behavior of the larval mosquito Aedes aegypti are described. Four discrete behavioral states dominate larval behavior: wriggling, two distinct types of feeding, and quiescence. Feeding behaviors consist of foraging along the bottom of the container (substrate browsing), and stationary filter feeding while suspended from the surface film. Fed larvae respond to paroxetine with increased wriggling, and reductions in both feeding behaviors. In contrast, food-deprived larvae treated with paroxetine show no change in the proportion of time spent wriggling or feeding, but shift from stationary filter feeding to substrate browsing. Thus, actions of paroxetine in fed larvae are consistent with suppression of appetite and stimulation of wriggling, whereas paroxetine causes food deprived larvae to switch from one feeding behavior to another. Further analysis of unfed larvae revealed that paroxetine decreased the power stroke frequency during wriggling locomotion, but had no effect on the swimming velocity during either wriggling or substrate browsing. These data suggest that: (1) serotonergic pathways may trigger shifts between distinct behaviors by actions on higher level (brain) integrating centers where behaviors such as feeding and locomotion are coordinated; (2) these centers in fed and food deprived larvae respond differently to serotonergic stimulation suggesting sensory feedback from feeding status; and (3) serotonergic pathways also modulate central pattern generators of the nerve cord where the bursts of action potentials originate that drive the rhythmic muscle contractions of wriggling. KEY WORDS: Aedes aegypti, Mosquito, Behavior, Paroxetine, Serotonin, Feeding, SSRI, Appetite, Wriggling, Substrate browsing, Stationary filter feeding en
dc.format.extent 10 pages
dc.format.mimetype PDF
dc.language.iso en en
dc.publisher The Company of Biologists en
dc.subject.lcsh Aedes aegypti
dc.subject.lcsh Mosquito -- Food
dc.subject.lcsh Paroxetine
dc.title Modulation of Appetite and Feeding Behavior of the Larval Mosquito Aedes aegypti by the Serotonin-selective Reuptake Inhibitor Paroxetine: Shifts Between Distinct Feeding Modes and the Influence of Feeding Status en
dc.type Article en

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search IUScholarWorks

Advanced Search


My Account