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dc.contributor.author Ann-Sophie Barwich
dc.contributor.other David Miller
dc.creator abarwich@iu.edu
dc.date.accessioned 2021-01-29T16:20:21Z
dc.date.available 2021-01-29T16:20:21Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/2022/26207
dc.description.abstract This paper tells the story of G-protein coupled receptors (GPCRs), one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to conceptually coordinate measurable effects distinctly to a specific object. We show that a scientific entity, such as GPCRs, is assigned varying degrees of reality throughout different stages of its discovery. The criteria of its reality, we further claim, cannot be made independently of the question about how this object becomes a standard by which the reality of neighbouring elements of enquiry is evaluated.
dc.format talk
dc.relation.ispartofseries 5; Open
dc.relation.isversionof Downstream publication: Barwich, Ann-Sophie. (2017) "The manipulability of what? The history of G-protein coupled receptors." Biology & Philosophy, 32, 1317-1339.
dc.subject contemporary
dc.subject scientific instruments, experiment, history
dc.subject biology, physiology
dc.subject the discovery of the olfactory receptors, a historicised perspective on scientific discovery
dc.title Sensing the Unknown: Historicising the Discoverability of the Olfactory Receptors within the Life on an Experimental System
dc.identifier.doi 10.1007/s10539-017-9608-9


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  • &HPS5 [26]
    26–28 June, 2014 – Institute Vienna Circle, Austria

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