Show simple item record Skinner, Owen S. en Havugimana, Pierre C. en Haverland, Nicole A. en Fornelli, Luca en Early, Bryan P. en Greer, Joseph B. en Fellers, Ryan T. en Durbin, Kenneth R. en Do Vale, Luis H. F. en Melani, Rafael D. en Seckler, Henrique S. en Nelp, Micah T. en Belov, Mikhail E. en Horning, Stevan R. en Makarov, Alexander A. en LeDuc, Richard D. en Bandarian, Vahe en Compton, Philip D. en Kelleher, Neil L. en 2015-12-16T19:29:05Z en 2015-12-16T19:29:05Z en
dc.identifier.citation TBD en
dc.identifier.uri en
dc.description.abstract Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we report a computational search strategy for hierarchical top-down analysis, identification, and scoring of multi-proteoform complexes by native mass spectrometry. en
dc.description.sponsorship The authors thank members of the Kelleher research group and Prof. V. Wysocki for helpful discussions and advice. O.S.S. is supported by a U. S. National Science Foundation Graduate Research Fellowship (2014171659). P.C.H. is a recipient of a Northwestern University's Chemistry of Life Processes Institute Postdoctoral Fellowship Award. L.H.F.D.V. is supported under CNPq research grant 202011/2012-7 from the Brazilian government. H.S.S is supported under the Science Without Borders scholarship 88888.075416/2013-00 from the Coordination for the Improvement of Higher Education Personnel, under the Brazilian government. This work was supported by grants from the W.M. Keck Foundation (DT061512) and the U.S. National Institutes of Health (GM067193) to N.L.K. en
dc.publisher Nature Publishing Group en
dc.relation.uri en
dc.rights Creative Commons Attribution 4.0 en
dc.rights.uri en
dc.subject Native Mass Spectrometry, Proteomics, Protein Complexes en
dc.title An informatic framework for decoding protein complexes by top-down mass spectrometry en
dc.type Dataset en
dc.altmetrics.display false en

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