Show simple item record Woodka, A.C. en Butler, P.D. en Porcar, L. en Farago, B. en Nagao, M. en 2014-10-30T19:11:09Z en 2014-10-30T19:11:09Z en 2012 en
dc.identifier.citation Woodka, A. C., Butler, P. D., Porcar, L., Farago, B., & Nagao, M. (2012). Lipid bilayers and membrane dynamics: Insight into thickness fluctuations. Physical Review Letters, 109(5), 05810. en
dc.description.abstract Thickness fluctuations have long been predicted in biological membranes but never directly observed experimentally. Here, we utilize neutron spin echo spectroscopy to experimentally reveal such fluctuations in a pure, fully saturated, phosphocholine lipid bilayer system. These fluctuations appear as an excess in the dynamics of undulation fluctuations. Like the bending rigidity, the thickness fluctuations change dramatically as the lipid transition temperature is crossed, appearing to be completely suppressed below the transition. Above the transition, the relaxation rate is on the order of 100 ns and is independent of temperature. The amplitude of the thickness fluctuations is $3.7 \AA ±0.7 \AA$, which agrees well with theoretical calculations and molecular dynamics simulations. The dependence of the fluctuations on lipid tail lengths is also investigated and determined to be minimal in the range of 14 to 18 carbon tails. en
dc.language.iso en_US en
dc.publisher American Physical Society en
dc.relation.isversionof en
dc.rights © 2012 American Physical Society en
dc.subject Bending rigidity en
dc.subject Bilayer systems en
dc.subject Membrane dynamics en
dc.subject Molecular dynamics simulations en
dc.subject Neutron spin echo spectroscopies en
dc.subject Phosphocholine en
dc.subject Relaxation rates en
dc.subject Tail length en
dc.subject Theoretical calculations en
dc.subject Thickness fluctuations en
dc.subject Cytology en
dc.subject Dynamics en
dc.subject Molecular dynamics en
dc.subject Lipid bilayers en
dc.title Lipid Bilayers and Membrane Dynamics: Insight into Thickness Fluctuations en
dc.type Article en
dc.altmetrics.display true en

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