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dc.contributor.author Andasari, V. en
dc.contributor.author Roper, R.T. en
dc.contributor.author Swat, M.H. en
dc.contributor.author Chaplain, M.A.J. en
dc.date.accessioned 2014-08-06T18:46:06Z en
dc.date.available 2014-08-06T18:46:06Z en
dc.date.issued 2012 en
dc.identifier.citation Andasari V, Roper RT, Swat MH, Chaplain MAJ (2012) Integrating Intracellular Dynamics Using CompuCell3D and Bionetsolver: Applications to Multiscale Modelling of Cancer Cell Growth and Invasion. PLoS ONE 7(3): e33726. doi:10.1371/journal.pone.0033726 en
dc.identifier.uri http://hdl.handle.net/2022/18554
dc.description.abstract In this paper we present a multiscale, individual-based simulation environment that integrates CompuCell3D for lattice-based modelling on the cellular level and Bionetsolver for intracellular modelling. CompuCell3D or CC3D provides an implementation of the lattice-based Cellular Potts Model or CPM (also known as the Glazier-Graner-Hogeweg or GGH model) and a Monte Carlo method based on the metropolis algorithm for system evolution. The integration of CC3D for cellular systems with Bionetsolver for subcellular systems enables us to develop a multiscale mathematical model and to study the evolution of cell behaviour due to the dynamics inside of the cells, capturing aspects of cell behaviour and interaction that is not possible using continuum approaches. We then apply this multiscale modelling technique to a model of cancer growth and invasion, based on a previously published model of Ramis-Conde et al. (2008) where individual cell behaviour is driven by a molecular network describing the dynamics of E-cadherin and $\beta$-catenin. In this model, which we refer to as the centre-based model, an alternative individual-based modelling technique was used, namely, a lattice-free approach. In many respects, the GGH or CPM methodology and the approach of the centre-based model have the same overall goal, that is to mimic behaviours and interactions of biological cells. Although the mathematical foundations and computational implementations of the two approaches are very different, the results of the presented simulations are compatible with each other, suggesting that by using individual-based approaches we can formulate a natural way of describing complex multi-cell, multiscale models. The ability to easily reproduce results of one modelling approach using an alternative approach is also essential from a model cross-validation standpoint and also helps to identify any modelling artefacts specific to a given computational approach. en
dc.language.iso en_US en
dc.publisher Public Library of Science en
dc.relation.isversionof https://doi.org/10.1371/journal.pone.0033726 en
dc.rights © 2012 Andasari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.rights.uri http://creativecommons.org/licenses/by-sa/3.0/ en
dc.subject beta catenin en
dc.subject uvomorulin en
dc.subject cadherin en
dc.subject algorithm en
dc.subject article en
dc.subject cancer cell en
dc.subject cancer growth en
dc.subject cancer invasion en
dc.subject cell adhesion en
dc.subject cell function en
dc.subject computer prediction en
dc.subject computer program en
dc.subject controlled study en
dc.subject information processing en
dc.subject intermethod comparison en
dc.subject mathematical model en
dc.subject Monte Carlo method en
dc.subject simulation en
dc.subject animal en
dc.subject biological model en
dc.subject cell proliferation en
dc.subject computer simulation en
dc.subject human en
dc.subject metabolism en
dc.subject multicellular spheroid en
dc.subject neoplasm en
dc.subject pathology en
dc.subject Animals en
dc.subject beta Catenin en
dc.subject Cadherins en
dc.subject Cell Proliferation en
dc.subject Computer Simulation en
dc.subject Humans en
dc.subject Models, Biological en
dc.subject Monte Carlo Method en
dc.subject Neoplasm Invasiveness en
dc.subject Neoplasms en
dc.subject Spheroids, Cellular en
dc.title Integrating intracellular dynamics using CompuCell3D and bionetsolver: Applications to multiscale modelling of cancer cell growth and invasion en
dc.type Article en


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