The Consortium for Top Down Proteomics was established in 2012 with the following mission:
To promote innovative research, collaboration and education accelerating the comprehensive analysis of intact proteins.
The consortium exists to bring together disparate researchers in top down proteomics and to educate the world on the study of proteins in the intact state.
A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The method was used to test the hypothesis that ...
O’Brien, John P.; Li, Wenzong; Zhang, Yan; Brodbelt, Jennifer S.
Ultraviolet photodissociation (UVPD) mass spectrometry (MS) was used to characterize the sequences of proteins in native protein-ligand and protein-protein complexes and to provide auxiliary information about the binding ...
Intact protein characterization using mass spectrometry thus far has been achieved at the cost of throughput. Presented here is the application of 193 nm ultraviolet photodissociation (UVPD) for top down identification and ...
Li, Yihan; Compton, Philip D.; Tran, John C.; Ntai, Ioanna; Kelleher, Neil L.(Wiley VCH (Proteomics), 1/14/2014)
The direct analysis of intact proteins via mass spectrometry offers compelling advantages in comparison to alternative methods due to the direct and unambiguous identification and characterization of protein sequences it ...
The ability to study organisms by direct analysis of their proteomes without digestion via mass spectrometry has benefited greatly from recent advances in separation techniques, instrumentation, and bioinformatics. However, ...