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Consortium for Top Down Proteomics (CTDP)
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The Consortium for Top Down Proteomics was established in 2012 with the following mission:
To promote innovative research, collaboration and education accelerating the comprehensive analysis of intact proteins.
The consortium exists to bring together disparate researchers in top down proteomics and to educate the world on the study of proteins in the intact state.
Collections in this community
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Data [15]
Recent Submissions
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(American Journal of Transplantation, 2017)Biomarker profiles diagnostic of acute rejection (AR) in liver transplant (LT) recipients could enhance the diagnosis and management of recipients. Our aim was to identify diagnostic proteoform-resolved signatures for AR ...
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(Nature Protocols, 2016-11)Top-down proteomics (TDP) by mass spectrometry (MS) has become increasingly popular in translational spheres as researchers discern the value of proteoform-resolved measurements. The advent of robust prefractionation ...
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(American Chemical Society, 2016)The National High Magnetic Field Laboratory (NHMFL) recently installed a 21T FT-ICR mass spectrometer, which is part of the NHMFL FT-ICR User Facility and available to all qualified users. Here, we demonstrate top-down ...
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(Forthcoming, 2016-08)Over the past decade, developments in high resolution mass spectrometry have enabled the high throughput analysis of intact proteins from complex proteomes, leading to the identification of thousands of proteoforms. ...
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(Forthcoming, )Within the last five years, top down proteomics (TDP) has emerged as a high throughput technique for protein identification in addition to characterization and quantitation of thousands of modified proteoforms. Here, a ...
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(Methods in Molecular Biology, Springer, )Traditional bottom-up mass spectrometry-based proteomics relies on the use of an enzyme, often trypsin, to generate small peptides (typically < 25 amino acids long). In top-down proteomics, proteins remain intact and are ...
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(2014-07-23)Introduction to the computing challenges in working with genomics-scale data and the possible solutions.
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(2014-07-22)introduction to running genomics softwares on a high performance computing systems.
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(Methods in Molecular Biology, Springer, 2016)Traditional bottom-up mass spectrometry-based proteomics relies on the use of an enzyme, often trypsin, to generate small peptides (typically < 25 amino acids long). In top-down proteomics, proteins remain intact and are ...
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(Proteomics, 2016-02-19)Recent studies utilizing transcriptomics, metabolomics, and bottom up proteomics have identified molecular signatures of kidney allograft pathology. Although these results make significant progress toward non-invasive ...
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(Nature Publishing Group, )Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein ...
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(Journal of Proteomics, 2015-05-04)Measuring post-translational modifications on transcription factors by targeted mass spectrometry is hampered by low protein abundance and inefficient isolation. Here, we utilized HaloTag technology to overcome these ...
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Characterization of Native Protein Complexes Using Ultraviolet Photodissociation Mass Spectrometry Ultraviolet photodissociation (UVPD) mass spectrometry (MS) was used to characterize the sequences of proteins in native protein-ligand and protein-protein complexes and to provide auxiliary information about the binding ...
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(Scienctific Reports, 2014-07-23)A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases and controls. The method was used to test the hypothesis that ...
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(2/21/2014)Intact protein characterization using mass spectrometry thus far has been achieved at the cost of throughput. Presented here is the application of 193 nm ultraviolet photodissociation (UVPD) for top down identification and ...
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(Wiley VCH (Proteomics), 1/14/2014)The direct analysis of intact proteins via mass spectrometry offers compelling advantages in comparison to alternative methods due to the direct and unambiguous identification and characterization of protein sequences it ...
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(2014)The ability to study organisms by direct analysis of their proteomes without digestion via mass spectrometry has benefited greatly from recent advances in separation techniques, instrumentation, and bioinformatics. However, ...