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List of base-pair substitutions found in 34 mutation accumulation lines of MutL deficient (MutL-) strain of E. coli PFM2 from Lee et al. PNAS (2012) - doi:10.1073/pnas.1210309109

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dc.contributor.author Lee, Heewook
dc.contributor.author Popodi, Ellen
dc.contributor.author Tang, Haixu
dc.contributor.author Foster, Patricia L
dc.date.accessioned 2012-12-10T18:36:48Z
dc.date.available 2012-12-10T18:36:48Z
dc.date.issued 2012-09-18
dc.identifier.citation Lee, H., Popodi, E., Tang, H., & Foster, P. L. (2012). Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing. Proceedings of the National Academy of Sciences. en_US
dc.identifier.uri http://hdl.handle.net/2022/15192
dc.description.abstract List of base-pair substitutions found in 34 mutation accumulation lines of MutL deficient (MutL-) strain of E. coli PFM2 en_US
dc.description.sponsorship Multidisciplinary University Research Initiative Award W911NF-09-1-0444 from the US Army Research Office en_US
dc.language.iso en_US en_US
dc.relation.isversionof The base-pair substitutions and short indels (up to 4bp) found in the MutL lines are also available in VCF file format(Variant Call Format) from NCBI's Short Read Archive (SRA) under the accession number SRA054031. The raw sequencing data is also available under the same accession number, Currently, the VCF file format is not fully supported by SRA so the data are available from the provisional page of SRA, located at http://trace.ncbi.nlm.nih.gov/Traces/sra/sra.cgi?view=provisional en_US
dc.subject evolution en_US
dc.subject mutation accumulation en_US
dc.subject neutral mutation en_US
dc.subject mutational hotspots en_US
dc.title List of base-pair substitutions found in 34 mutation accumulation lines of MutL deficient (MutL-) strain of E. coli PFM2 from Lee et al. PNAS (2012) - doi:10.1073/pnas.1210309109 en_US
dc.type Dataset en_US
dc.description.file Excel file format (xlsx). Each row is associated with a recovered base-pair substitution. The first column indicates the name of the MA line. The second column is the position of the base-pair substitution. The third, fourth, and fifth columns are the reference base, consensus base, and observed base, respectively. The reference base is taken from the reference genome (Ecoli K-12 MG1655, NC_000913.2 from NCBI). The consensus base is the base of the starting strain determined by sequencing of all MutL- MA lines [refer to Lee et al. PNAS (2012) ]. The observed base is the mutated base observed in the MA line designated by column 1. en_US


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