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dc.contributor.author Jeong, Jaesung
dc.contributor.author Lee, Junho
dc.contributor.author Ahn, Yong-Yeol
dc.contributor.author Choi, Myung-Kyu
dc.contributor.author Sohn, Yunkyu
dc.date.accessioned 2012-04-09T16:53:55Z
dc.date.available 2012-04-09T16:53:55Z
dc.date.issued 2011-05
dc.identifier.citation Sohn Y, Choi M-K, Ahn Y-Y, Lee J, Jeong J (2011) Topological Cluster Analysis Reveals the Systemic Organization of the Caenorhabditis elegans Connectome. PLoS Comput Biol 7(5): e1001139. doi:10.1371/journal.pcbi.1001139 en
dc.identifier.uri http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1001139 en
dc.identifier.uri http://hdl.handle.net/2022/14347
dc.description.abstract The modular organization of networks of individual neurons interwoven through synapses has not been fully explored due to the incredible complexity of the connectivity architecture. Here we use the modularity-based community detection method for directed, weighted networks to examine hierarchically organized modules in the complete wiring diagram (connectome) of Caenorhabditis elegans (C. elegans) and to investigate their topological properties. Incorporating bilateral symmetry of the network as an important cue for proper cluster assignment, we identified anatomical clusters in the C. elegans connectome, including a body-spanning cluster, which correspond to experimentally identified functional circuits. Moreover, the hierarchical organization of the five clusters explains the systemic cooperation (e.g., mechanosensation, chemosensation, and navigation) that occurs among the structurally segregated biological circuits to produce higher-order complex behaviors. en
dc.description.sponsorship This work was supported by CHUNG MoonSoul Research Center for BioInformation and BioElectronics (CMSC) in KAIST, the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. R01-2007-000-21094-0 and No. M10644000028-06N4400-02810) (J. Jeong). This work was also supported in part by a grant (M103KV010018-08K2201-01810) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea (J. Lee). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. en
dc.language.iso en_US en
dc.publisher PLoS en
dc.rights Copyright: 2011 Sohn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.title Topological Cluster Analysis Reveals the Systemic Organization of the Caenorhabditis elegans Connectome en
dc.type Article en


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