Show simple item record Mukhopadhyay, Suchetana Zlotnick, Adam 2012-01-03T22:19:34Z 2012-01-03T22:19:34Z 2010-12-28
dc.identifier.citation Virus assembly, allostery and antivirals Adam Zlotnick, Suchetana Mukhopadhyay Trends in Microbiology - 1 January 2011 (Vol. 19, Issue 1, pp. 14-23) en
dc.description.abstract Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems are structurally and biochemically well-characterized and are simplest-case paradigms of self-assembly. Published data suggest that capsid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level of conformational change. The hypothesis that allostery is a common theme in viruses suggests that deregulation of capsid and glycoprotein assembly by small molecule effectors will be an attractive antiviral strategy, as has been demonstrated with hepatitis B virus. en
dc.language.iso en_US en
dc.publisher Elsevier en
dc.relation.isversionof en
dc.rights Copyright 2010 Elsevier Ltd. en
dc.title Virus assembly, allostery, and antivirals en
dc.type Article en

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