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WENDI: A tool for finding non-obvious relationships between compounds and biological properties, genes, diseases and scholarly publications

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dc.contributor.author Zhu, Qian
dc.contributor.author Lajiness, Michael S.
dc.contributor.author Ding, Ying
dc.contributor.author Wild, David J.
dc.date.accessioned 2011-12-12T03:32:35Z
dc.date.available 2011-12-12T03:32:35Z
dc.date.issued 2010
dc.identifier.citation Zhu, Q., Lajiness, M. S., Ding, Y., & Wild, D. J. (2010). WENDI: A tool for finding non-obvious relationships between compounds and biological properties, genes, diseases and scholarly publications. Journal of Cheminformatics, 2(1). http://dx.doi.org/10.1186/1758-2946-2-6 en
dc.identifier.uri http://hdl.handle.net/2022/13963
dc.identifier.uri http://dx.doi.org/10.1186/1758-2946-2-6 en
dc.description.abstract Background: In recent years, there has been a huge increase in the amount of publicly-available and proprietary information pertinent to drug discovery. However, there is a distinct lack of data mining tools available to harness this information, and in particular for knowledge discovery across multiple information sources. At Indiana University we have an ongoing project with Eli Lilly to develop web-service based tools for integrative mining of chemical and biological information. In this paper, we report on the first of these tools, called WENDI (Web Engine for Non-obvious Drug Information) that attempts to find non-obvious relationships between a query compound and scholarly publications, biological properties, genes and diseases using multiple information sources. Results: We have created an aggregate web service that takes a query compound as input, calls multiple web services for computation and database search, and returns an XML file that aggregates this information. We have also developed a client application that provides an easy-to-use interface to this web service. Both the service and client are publicly available. Conclusions: Initial testing indicates this tool is useful in identifying potential biological applications of compounds that are not obvious, and in identifying corroborating and conflicting information from multiple sources. We encourage feedback on the tool to help us refine it further. We are now developing further tools based on this model. en
dc.language.iso en_US en
dc.publisher Chemistry Central
dc.rights © 2010 Zhu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.title WENDI: A tool for finding non-obvious relationships between compounds and biological properties, genes, diseases and scholarly publications en
dc.type Article en


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