Browsing by Author "Kelleher, Neil L."

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  • Savaryn, John P.; Toby, Timothy K.; Catherman, Adam D.; Fellers, Ryan T.; LeDuc, Richard D.; Thomas, Paul M.; Friedewald, John J.; Salomon, Daniel R.; Abecassis, Michael M.; Kelleher, Neil L. (Proteomics, 2016-02-19)
    Recent studies utilizing transcriptomics, metabolomics, and bottom up proteomics have identified molecular signatures of kidney allograft pathology. Although these results make significant progress toward non-invasive ...
  • Toby, Timothy K.; Fornelli, Luca; Kristina, Srzentic; DeHart, Caroline J.; Fellers, Ryan T.; LeDuc, Richard D.; Kyunggon, Kim; Thomas, Paul M.; Levitsky, Josh M.; Kelleher, Neil L. (Nature Protocols, 2016-11)
    Top-down proteomics (TDP) by mass spectrometry (MS) has become increasingly popular in translational spheres as researchers discern the value of proteoform-resolved measurements. The advent of robust prefractionation ...
  • Skinner, Owen S.; Havugimana, Pierre C.; Haverland, Nicole A.; Fornelli, Luca; Early, Bryan P.; Greer, Joseph B.; Fellers, Ryan T.; Durbin, Kenneth R.; Do Vale, Luis H. F.; Melani, Rafael D.; Seckler, Henrique S.; Nelp, Micah T.; Belov, Mikhail E.; Horning, Stevan R.; Makarov, Alexander A.; LeDuc, Richard D.; Bandarian, Vahe; Compton, Philip D.; Kelleher, Neil L. (Nature Publishing Group, )
    Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein ...
  • Li, Yihan; Compton, Philip D.; Tran, John C.; Ntai, Ioanna; Kelleher, Neil L. (Wiley VCH (Proteomics), 1/14/2014)
    The direct analysis of intact proteins via mass spectrometry offers compelling advantages in comparison to alternative methods due to the direct and unambiguous identification and characterization of protein sequences it ...
  • Toby, Timothy K.; Kim, Kyunggon; Thomas, Paul M.; Fellers, Ryan T.; LeDuc, Richard D.; Kelleher, Neil L.; Demetris, Anthony J.; Abecassis, Michael M.; Levitsky, Josh M. (American Journal of Transplantation, 2017)
    Biomarker profiles diagnostic of acute rejection (AR) in liver transplant (LT) recipients could enhance the diagnosis and management of recipients. Our aim was to identify diagnostic proteoform-resolved signatures for AR ...
  • Savaryn, John Paul; Skinner, Owen S.; Fornelli, Luca; Fellers, Ryan T.; Compton, Philip D.; Terhune, Scott S.; Abecassis, Mike M.; Kelleher, Neil L. (Journal of Proteomics, 2015-05-04)
    Measuring post-translational modifications on transcription factors by targeted mass spectrometry is hampered by low protein abundance and inefficient isolation. Here, we utilized HaloTag technology to overcome these ...

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